The ARHGEF12 Polyclonal Antibody (PACO02767) is a valuable tool for researchers studying ARHGEF12, a key protein involved in cell signaling and cytoskeleton reorganization. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.ARHGEF12, also known as Rho guanine nucleotide exchange factor 12, is a critical regulator of Rho GTPases, which play essential roles in cellular processes such as cell migration, adhesion, and proliferation.
Dysregulation of ARHGEF12 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.By targeting the ARHGEF12 protein, researchers can investigate its role in cellular functions and disease development, ultimately paving the way for the development of novel treatments and diagnostic tools. The ARHGEF12 Polyclonal Antibody is a valuable resource for studies in cell biology, cancer research, and drug discovery.
Antibody Name:
ARHGEF12 Antibody
Antibody SKU:
PACO02767
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human LARG.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; OncoproteinChromosomal Location of Human Ortholog: 11q23.3Cellular Component: cytoplasm; cytosolMolecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
