The ARHGEF11 Polyclonal Antibody (CAB7954) is a valuable tool for researchers studying the ARHGEF11 protein, which is involved in a variety of cellular processes including cell signaling and cytoskeletal reorganization. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the ARHGEF11 protein, this antibody allows for accurate detection and analysis in a wide range of cell types, making it an essential component for studies in cell biology and signal transduction.
ARHGEF11, also known as Rho guanine nucleotide exchange factor 11, is a key player in signaling pathways that regulate cell migration, adhesion, and proliferation. Dysregulation of ARHGEF11 has been implicated in diseases such as cancer and neurological disorders, making it a promising target for therapeutic intervention. By deciphering the function of ARHGEF11, researchers can gain valuable insights into disease mechanisms and potentially identify new treatment strategies to combat these conditions.
Product Name:
ARHGEF11 Rabbit Polyclonal Antibody
SKU:
CAB7954
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARHGEF11 (O15085).
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
9826
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using ARHGEF11 Rabbit pAb (CAB7954) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
