The ARHGEF10 Polyclonal Antibody (PAC007831) is a valuable tool for research focused on ARHGEF10, a Rho guanine nucleotide exchange factor implicated in cell signaling and cytoskeleton organization. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ARHGEF10 protein, researchers can efficiently detect and analyze its expression in a variety of cell types, making it an excellent choice for studies in cell biology and cancer research.
ARHGEF10 plays a crucial role in regulating cell morphology, movement, and proliferation through its activation of Rho GTPases. Its involvement in these signaling pathways makes it a promising target for investigating various cellular processes and diseases, including cancer and neurodevelopmental disorders. By understanding the function of ARHGEF10, researchers can gather insights that may lead to the development of novel therapeutic interventions targeting aberrant cell signaling pathways related to these conditions.
ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 8p23Cellular Component: centrosome; cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; kinesin bindingBiological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous systemDisease: Slowed Nerve Conduction Velocity, Autosomal Dominant
UniProt Protein Details:
NCBI Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]
