The ARHGDIG Polyclonal Antibody (PAC007829) is a powerful tool for researchers studying ARHGDIG, a protein involved in regulating cell signaling pathways. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot assays. By targeting the ARHGDIG protein, researchers can accurately detect and analyze its expression in various types of cells, making it an essential component for studies in cell signaling and cancer research.ARHGDIG, also known as Rho GDP-dissociation inhibitor gamma, plays a crucial role in modulating the activity of Rho GTPases, key regulators of cell migration, proliferation, and differentiation.
Dysregulation of ARHGDIG has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. By understanding the function of ARHGDIG, researchers can potentially identify novel therapeutic targets for these diseases, paving the way for new treatment strategies and improved patient outcomes.
Rho GDP dissociation inhibitor (GDI) γ;ARHGDIG;RHOGDI-3 ;
UniProt Protein Function:
RhoGDI gamma: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. Belongs to the Rho GDI family.Protein type: Inhibitor; Motility/polarity/chemotaxis; G protein regulator, misc.; Cell adhesionChromosomal Location of Human Ortholog: 16p13.3Cellular Component: membrane; cytoplasmic membrane-bound vesicle; cytosolMolecular Function: Rho GDP-dissociation inhibitor activity; GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; regulation of protein localization; small GTPase mediated signal transduction; negative regulation of cell adhesion; Rho protein signal transduction; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
