The ARHGDIA Polyclonal Antibody (CAB13468) is a valuable tool for researchers investigating the function of ARHGDIA, a protein involved in regulating cell signaling pathways and cytoskeletal dynamics. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is specifically validated for use in Western blot applications.ARHGDIA, also known as Rho GDP-dissociation inhibitor alpha, is a key player in the regulation of Rho GTPases, which are crucial for cellular processes such as cell migration, adhesion, and proliferation.
Dysregulation of ARHGDIA has been implicated in various diseases, including cancer and neurological disorders, making it an important target for therapeutic interventions.By binding to ARHGDIA, this polyclonal antibody enables researchers to detect and analyze the protein in a range of cell types, facilitating studies in cell biology, oncology, and neuroscience. Understanding the function of ARHGDIA and its interactions can provide valuable insights into disease mechanisms and potential treatment strategies.
Product Name:
[KO Validated] RhoGDI Rabbit Polyclonal Antibody
SKU:
CAB13468
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human RhoGDI (NP_001172006.1).
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
396
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and RhoGDI knockout (KO) 293T cells, using RhoGDI antibody (CAB13468) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
