UniProt Protein Function: | ARHGAP9: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; Cell adhesion; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 12q13.3Cellular Component: cytosolMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BRR9 |
NCBI GenInfo Identifier: | 122939149 |
NCBI Gene ID: | 64333 |
NCBI Accession: | NP_001073625.1 |
UniProt Secondary Accession: | Q9BRR9,Q8NAF3, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74, B4DVI3 E9PDX9 |
UniProt Related Accession: | Q9BRR9 |
Molecular Weight: | 83,260 Da |
NCBI Full Name: | rho GTPase-activating protein 9 isoform 3 |
NCBI Synonym Full Names: | Rho GTPase activating protein 9 |
NCBI Official Symbol: | ARHGAP9Â Â |
NCBI Official Synonym Symbols: | 10C; RGL1Â Â |
NCBI Protein Information: | rho GTPase-activating protein 9; rho-type GTPase-activating protein 9 |
UniProt Protein Name: | Rho GTPase-activating protein 9 |
UniProt Synonym Protein Names: | Rho-type GTPase-activating protein 9 |
Protein Family: | |
UniProt Gene Name: | ARHGAP9Â Â |
UniProt Entry Name: | RHG09_HUMAN |