The ARHGAP42 Polyclonal Antibody (PAC04658) is a valuable tool for researchers studying ARHGAP42, a protein involved in cell signaling and cytoskeletal organization. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and immunofluorescence applications.ARHGAP42, a Rho GTPase-activating protein, regulates the activity of Rho family GTPases, key players in controlling cell shape, movement, and proliferation. Dysregulation of ARHGAP42 has been linked to various diseases, including cancer and neurological disorders.
By targeting ARHGAP42, researchers can gain insight into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.With its ability to detect and quantify ARHGAP42 in a variety of cell types and experimental settings, the ARHGAP42 Polyclonal Antibody is a valuable tool for advancing research in cell biology, cancer biology, and neurobiology. Researchers can rely on this antibody to accurately assess the expression and localization of ARHGAP42, contributing to a deeper understanding of its function and potential role in disease pathology.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO46458 at dilution of 1:100.
Western Blot. Positive WB detected in: Human placenta tissue. All lanes: ARHGAP42 antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 99 kDa. Observed band size: 99 kDa.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46458 at dilution of 1:100.
Background:
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.
Synonyms:
Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42), ARHGAP42, GRAF3
UniProt Protein Function:
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.
UniProt Protein Details:
NCBI Summary:
This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
