The ARHGAP4 Polyclonal Antibody (CAB18338) is a valuable tool for researchers studying ARHGAP4, a protein involved in cell signaling and cytoskeletal dynamics. This rabbit polyclonal antibody is highly specific for human samples and is validated for use in Western blot applications. By binding to the ARHGAP4 protein, this antibody enables the detection and analysis of ARHGAP4 in various cell types, making it essential for studies in cell biology and cancer research.ARHGAP4, also known as Rho GTPase-activating protein 4, plays a crucial role in the regulation of Rho GTPases, which are key regulators of cell morphology, migration, and proliferation. Dysregulation of ARHGAP4 has been implicated in cancer progression and metastasis, making it an important target for therapeutic intervention.
By elucidating the function of ARHGAP4, researchers can gain insights into the mechanisms underlying cancer development and potentially identify novel treatment strategies.Overall, the ARHGAP4 Polyclonal Antibody (CAB18338) offers researchers a reliable tool for investigating the biological functions of ARHGAP4 and its role in disease pathology. Its high specificity and sensitivity make it an excellent choice for studies aiming to elucidate the signaling pathways and regulatory mechanisms involving ARHGAP4.
Product Name:
ARHGAP4 Rabbit Polyclonal Antibody
SKU:
CAB18338
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human ARHGAP4 (NP_001158213.1).
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
393
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using ARHGAP4 Rabbit pAb (CAB18338) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
