The ARHGAP29 Polyclonal Antibody (PAC036082) is a valuable tool for researchers studying ARHGAP29, a protein involved in cell migration and cytoskeletal organization. This antibody, produced in rabbits, is highly specific to human samples and is ideal for use in Western blotting applications. By targeting the ARHGAP29 protein, this antibody allows for the detection and analysis of ARHGAP29 in various cell types, making it an essential component for studies in cell biology and cancer research.
ARHGAP29, also known as Rho GTPase activating protein 29, is a key regulator of Rho GTPase signaling pathways that control cell migration and invasion. Understanding the role of ARHGAP29 in these processes is crucial for unraveling its potential involvement in cancer metastasis and other diseases. By studying ARHGAP29, researchers can gain insights into potential therapeutic targets for diseases related to abnormal cell migration and invasion.
Antibody Name:
ARHGAP29 Antibody (PACO36082)
Antibody SKU:
PACO36082
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Rho GTPase-activating protein 29 protein (161-392AA)
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Synonyms:
Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29), ARHGAP29, PARG1
UniProt Protein Function:
ARHGAP29: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 1p22.1Cellular Component: cytoplasm; cytosolMolecular Function: GTPase activator activity; PDZ domain bindingBiological Process: regulation of small GTPase mediated signal transduction; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]
