| UniProt Protein Function: | ARHGAP27: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 17q21.31Cellular Component: cytoplasm; intracellular; nucleoplasm; nucleusMolecular Function: GTPase activator activity; SH3 domain bindingBiological Process: positive regulation of GTPase activity; receptor-mediated endocytosis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q6ZUM4 |
| NCBI GenInfo Identifier: | 300669680 |
| NCBI Gene ID: | 201176 |
| NCBI Accession: | Q6ZUM4.3 |
| UniProt Secondary Accession: | Q6ZUM4,Q494U0, Q6NWZ8, Q8WY58, A4FU35, A8K3N5, C9JTF3 |
| UniProt Related Accession: | Q6ZUM4 |
| Molecular Weight: | 28,192 Da |
| NCBI Full Name: | Rho GTPase-activating protein 27 |
| NCBI Synonym Full Names: | Rho GTPase activating protein 27 |
| NCBI Official Symbol: | ARHGAP27Â Â |
| NCBI Official Synonym Symbols: | PP905; SH3D20; SH3P20; CAMGAP1Â Â |
| NCBI Protein Information: | rho GTPase-activating protein 27 |
| UniProt Protein Name: | Rho GTPase-activating protein 27 |
| UniProt Synonym Protein Names: | CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; Rho-type GTPase-activating protein 27; SH3 domain-containing protein 20 |
| Protein Family: | Rho GTPase-activating protein |
| UniProt Gene Name: | ARHGAP27Â Â |
| UniProt Entry Name: | RHG27_HUMAN |
