The ARHGAP27 Polyclonal Antibody (PACO36718) is a valuable tool for researchers studying the protein ARHGAP27, which plays a crucial role in cellular processes such as cell migration and adhesion. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ARHGAP27 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in cell biology and cancer research.
ARHGAP27 is known for its involvement in regulating the activity of Rho GTPases, key signaling molecules that control cytoskeletal dynamics and cellular morphology. Dysregulation of ARHGAP27 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance in cellular function. By understanding the role of ARHGAP27, researchers can uncover new insights into disease mechanisms and potentially develop targeted therapies to manipulate cellular behavior.
Antibody Name:
ARHGAP27 Antibody (PACO36718)
Antibody SKU:
PACO36718
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Rho GTPase-activating protein 27 protein (1-300AA)
Immunohistochemistry of paraffin-embedded human lung cancer using PACO36718 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO36718 at dilution of 1:100.
Background:
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1.
Synonyms:
Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20), ARHGAP27, CAMGAP1 SH3D20
UniProt Protein Function:
ARHGAP27: Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 17q21.31Cellular Component: cytoplasm; intracellular; nucleoplasm; nucleusMolecular Function: GTPase activator activity; SH3 domain bindingBiological Process: positive regulation of GTPase activity; receptor-mediated endocytosis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
