The ARHGAP26 Polyclonal Antibody (PACO07824) is a valuable tool for researchers studying the ARHGAP26 protein, a key regulator of cell signaling pathways involved in cell migration and invasion. This antibody, generated in rabbits, is specifically designed for use in Western blot applications and demonstrates high reactivity with human samples.ARHGAP26, also known as Rho GTPase-activating protein 26, plays a crucial role in modulating the activity of Rho family GTPases, which are essential for the regulation of cytoskeletal dynamics and cell motility. Dysregulation of ARHGAP26 has been implicated in various diseases, including cancer, where increased expression has been associated with tumor progression and metastasis.
By targeting ARHGAP26 with this polyclonal antibody, researchers can investigate its functions in different cell types and pathological conditions, providing valuable insights into the molecular mechanisms underlying cancer progression and potential therapeutic targets. This antibody is a valuable tool for studies in cell biology, cancer research, and drug development aiming to target ARHGAP26 for therapeutic interventions.
Rho GTPase activating protein 26;ARHGAP26;FLJ42530;GRAF;KIAA0621;OPHN1L;OPHN1L1 ;
UniProt Protein Function:
ARHGAP26: GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/Rho; Oncoprotein; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 5q31Cellular Component: cytosolMolecular Function: GTPase activator activity; phospholipid binding; protein bindingBiological Process: regulation of small GTPase mediated signal transductionDisease: Juvenile Myelomonocytic Leukemia
UniProt Protein Details:
NCBI Summary:
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
