The ARHGAP24 Antibody (PACO07822) is a polyclonal antibody specifically designed for research involving ARHGAP24, a Rho GTPase-activating protein that plays a key role in regulating cell migration and actin cytoskeleton dynamics. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ARHGAP24 is known to be involved in various cellular processes, including cell adhesion, proliferation, and migration, making it a critical target for studies in cell biology and cancer research. By binding to the ARHGAP24 protein, this antibody enables accurate detection and analysis in a variety of cell types, providing valuable insights into the mechanisms underlying cell movement and invasion.
The significance of ARHGAP24 in cancer progression and metastasis makes it a promising target for the development of novel therapeutics aimed at inhibiting tumor spread. Furthermore, understanding the role of ARHGAP24 in cellular signaling pathways may lead to the identification of potential biomarkers for cancer diagnosis and prognosis. The ARHGAP24 Antibody is a valuable tool for researchers seeking to unravel the complex functions of ARHGAP24 and its implications in disease pathology.
Rho GTPase activating protein 24;ARHGAP24;DKFZp564B1162;FILGAP;FLJ33877;RC-GAP72;RCGAP72;p73;p73RhoGAP ;FILGAP
UniProt Protein Function:
ARHGAP24: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; Motility/polarity/chemotaxis; GAPsChromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytosolMolecular Function: GTPase activator activity; protein bindingBiological Process: regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Filamin-A-associated RhoGAP; FilGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP
