| UniProt Protein Function: | ARHGAP24: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; Motility/polarity/chemotaxis; GAPsChromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytosolMolecular Function: GTPase activator activity; protein bindingBiological Process: regulation of small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8N264 |
| NCBI GenInfo Identifier: | 134035016 |
| NCBI Gene ID: | 83478 |
| NCBI Accession: | Q8N264.2 |
| UniProt Secondary Accession: | Q8N264,Q4KMG1, Q6ZNV3, Q86TI5, Q86WE4, Q9H0T6 |
| UniProt Related Accession: | Q8N264 |
| Molecular Weight: | 28,221 Da |
| NCBI Full Name: | Rho GTPase-activating protein 24 |
| NCBI Synonym Full Names: | Rho GTPase activating protein 24 |
| NCBI Official Symbol: | ARHGAP24Â Â |
| NCBI Official Synonym Symbols: | p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAPÂ Â |
| NCBI Protein Information: | rho GTPase-activating protein 24 |
| UniProt Protein Name: | Rho GTPase-activating protein 24 |
| UniProt Synonym Protein Names: | Filamin-A-associated RhoGAP; FilGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP |
| Protein Family: | Rho GTPase-activating protein |
| UniProt Gene Name: | ARHGAP24Â Â |
| UniProt Entry Name: | RHG24_HUMAN |
