The ARHGAP23 Polyclonal Antibody (PACO04832) is a valuable tool for researchers studying ARHGAP23, a protein involved in cell signaling and regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot and immunofluorescence applications. By targeting the ARHGAP23 protein, this antibody allows for the detection and analysis of ARHGAP23 expression in various cell types, making it ideal for investigations in cell biology and cancer research.ARHGAP23, also known as Rho GTPase-activating protein 23, plays a crucial role in regulating the activity of Rho family GTPases, key regulators of cell shape, motility, and proliferation.
Dysregulation of ARHGAP23 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. Therefore, understanding the function of ARHGAP23 is essential for developing targeted therapies that modulate Rho GTPase signaling pathways in disease settings.Overall, the ARHGAP23 Polyclonal Antibody (PACO04832) is a reliable tool for researchers interested in exploring the role of ARHGAP23 in cellular processes and disease development. Its specificity and sensitivity make it a valuable asset for studies aiming to decipher the molecular mechanisms underlying ARHGAP23 function.
Antibody Name:
ARHGAP23 Antibody
Antibody SKU:
PACO04832
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human ARHGAP23.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ARHGAP23; KIAA1501; Rho GTPase-activating protein 23; Rho-type GTPase-activating protein 23
UniProt Protein Function:
ARHGAP23: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 17q12Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
