The ARHGAP20 Polyclonal Antibody (PACO07821) is specifically designed for research related to ARHGAP20, a protein involved in regulating cell migration and adhesion. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding to the ARHGAP20 protein, this antibody facilitates the detection and analysis of ARHGAP20 in various cell types, making it an ideal tool for studies in cell biology and cancer research.ARHGAP20, also known as Rho GTPase-activating protein 20, plays a crucial role in modulating the activity of Rho GTPases, which are key regulators of cytoskeletal dynamics and cellular processes such as cell migration and adhesion.
Dysregulation of ARHGAP20 has been implicated in various diseases, including cancer and neurological disorders. Therefore, investigating the function of ARHGAP20 is essential for understanding the underlying mechanisms of these conditions and developing targeted therapies to modulate ARHGAP20 activity.
Rho GTPase activating protein 20;ARHGAP20;KIAA1391;RARHOGAP ;
UniProt Protein Function:
ARHGAP20: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Tumor suppressor; GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 11q23.1Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
rho GTPase-activating protein 20; rho-type GTPase-activating protein 20; RA and RhoGAP domain containing protein; rho GTPase activating protein 20 variant 2
