The ARHGAP19 Polyclonal Antibody (PACO35782) is a valuable tool for researchers studying the ARHGAP19 protein, a key regulator of cell migration and invasion. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.ARHGAP19 is known for its role in controlling the activity of Rho GTPases, which are critical for cytoskeletal dynamics and cell movement. By targeting ARHGAP19 with this antibody, researchers can detect and analyze the protein in a variety of cell types, providing insights into its function in cell migration processes.
With its potential implications in cancer metastasis and other diseases characterized by abnormal cell movement, studying ARHGAP19 with this antibody could lead to new therapeutic strategies for intervention. By understanding the molecular mechanisms controlled by ARHGAP19, researchers can uncover novel targets for drug development aimed at modulating cell migration and invasion.
Antibody Name:
ARHGAP19 Antibody (PACO35782)
Antibody SKU:
PACO35782
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Rho GTPase-activating protein 19 protein (1-494AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO35782 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO35782 at dilution of 1:100.
Background:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Synonyms:
Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19), ARHGAP19
UniProt Protein Function:
ARHGAP19: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. 7 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 10q24.1Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
