| UniProt Protein Function: | ARHGAP17: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1. 7 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: GTPase activator activity; protein bindingBiological Process: regulation of small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q68EM7 |
| NCBI GenInfo Identifier: | 74736331 |
| NCBI Gene ID: | 55114 |
| NCBI Accession: | Q68EM7.1 |
| UniProt Secondary Accession: | Q68EM7,Q6ZUS4, Q7Z2F2, Q8NDG2, Q96KS2, Q96KS3, Q96SS8 Q9BVF6, Q9H8U5, Q9NW54 |
| UniProt Related Accession: | Q68EM7 |
| Molecular Weight: | 42,512 Da |
| NCBI Full Name: | Rho GTPase-activating protein 17 |
| NCBI Synonym Full Names: | Rho GTPase activating protein 17 |
| NCBI Official Symbol: | ARHGAP17Â Â |
| NCBI Official Synonym Symbols: | PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH-1; MSTP038; MSTP066; MSTP110Â Â |
| NCBI Protein Information: | rho GTPase-activating protein 17 |
| UniProt Protein Name: | Rho GTPase-activating protein 17 |
| UniProt Synonym Protein Names: | Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1 |
| Protein Family: | Rho GTPase-activating protein |
| UniProt Gene Name: | ARHGAP17Â Â |
| UniProt Entry Name: | RHG17_HUMAN |
