Anti-ARHGAP15 Antibody (PACO15507)

Antibody Name:	ARHGAP15 Antibody (PACO15507)
Antibody SKU:	PACO15507
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human ARHGAP15

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15507(ARHGAP15 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15507(ARHGAP15 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:

RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]). GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

Synonyms:

Rho GTPase activating protein 15

UniProt Protein Function:	ARHGAP15: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 2q22.2-q22.3Cellular Component: membrane; cytosolBiological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:	RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
UniProt Code:	Q53QZ3
NCBI GenInfo Identifier:	28274758
NCBI Gene ID:	55843
NCBI Accession:	AAO34684.1
UniProt Secondary Accession:	Q53QZ3,Q53R36, Q53RD7, Q53RT6, Q53SX9, Q584N9, Q6PJE6 Q86WP1, Q8IXX1, Q9NRL8
UniProt Related Accession:	Q53QZ3
Molecular Weight:
NCBI Full Name:	ARHGAP15
NCBI Synonym Full Names:	Rho GTPase activating protein 15
NCBI Official Symbol:	ARHGAP15
NCBI Official Synonym Symbols:	BM046
NCBI Protein Information:	rho GTPase-activating protein 15; rho-type GTPase-activating protein 15
UniProt Protein Name:	Rho GTPase-activating protein 15
UniProt Synonym Protein Names:	ArhGAP15; Rho-type GTPase-activating protein 15
Protein Family:	Rho GTPase-activating protein
UniProt Gene Name:	ARHGAP15
UniProt Entry Name:	RHG15_HUMAN

Antibodies

ARHGAP15 Antibody (PACO07819)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)