The ARHGAP15 Polyclonal Antibody (PACO15506) is a valuable tool for researchers studying ARHGAP15, a protein involved in cell signaling and regulation of the actin cytoskeleton. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot assays. By targeting the ARHGAP15 protein, this antibody enables the detection and analysis of ARHGAP15 expression in a variety of cell types, making it ideal for investigations in cell biology and cancer research.
ARHGAP15, a Rho GTPase-activating protein, plays a pivotal role in cellular processes such as cell migration, adhesion, and cytoskeletal dynamics. Its involvement in these pathways suggests its potential relevance to cancer metastasis and tumor progression, making it a promising target for therapeutic intervention. By understanding the function of ARHGAP15, researchers can gain insights into the mechanisms underlying cancer development and potentially identify new approaches for cancer treatment.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15506(ARHGAP15 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, 293T cells, Primary antibody: PACO15506(ARHGAP15 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15506(ARHGAP15 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RHO GTPases regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
Synonyms:
Rho GTPase activating protein 15
UniProt Protein Function:
ARHGAP15: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 2q22.2-q22.3Cellular Component: membrane; cytosolBiological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
