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ARHGAP15 Antibody (PACO15506)

SKU:
PACO15506
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ARHGAP15 Antibody PACO15506
  • ARHGAP15 Antibody PACO15506
  • ARHGAP15 Antibody PACO15506
€339
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Description

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ARHGAP15 Antibody (PACO15506)

The ARHGAP15 Polyclonal Antibody (PACO15506) is a valuable tool for researchers studying ARHGAP15, a protein involved in cell signaling and regulation of the actin cytoskeleton. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot assays. By targeting the ARHGAP15 protein, this antibody enables the detection and analysis of ARHGAP15 expression in a variety of cell types, making it ideal for investigations in cell biology and cancer research.

ARHGAP15, a Rho GTPase-activating protein, plays a pivotal role in cellular processes such as cell migration, adhesion, and cytoskeletal dynamics. Its involvement in these pathways suggests its potential relevance to cancer metastasis and tumor progression, making it a promising target for therapeutic intervention. By understanding the function of ARHGAP15, researchers can gain insights into the mechanisms underlying cancer development and potentially identify new approaches for cancer treatment.

Antibody Name:ARHGAP15 Antibody (PACO15506)
Antibody SKU:PACO15506
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human ARHGAP15
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15506(ARHGAP15 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageGel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, 293T cells, Primary antibody: PACO15506(ARHGAP15 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15506(ARHGAP15 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:RHO GTPases regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
Synonyms:Rho GTPase activating protein 15
UniProt Protein Function:ARHGAP15: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 2q22.2-q22.3Cellular Component: membrane; cytosolBiological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
UniProt Code:Q53QZ3
NCBI GenInfo Identifier:28274758
NCBI Gene ID:55843
NCBI Accession:AAO34684.1
UniProt Secondary Accession:Q53QZ3,Q53R36, Q53RD7, Q53RT6, Q53SX9, Q584N9, Q6PJE6 Q86WP1, Q8IXX1, Q9NRL8
UniProt Related Accession:Q53QZ3
Molecular Weight:
NCBI Full Name:ARHGAP15
NCBI Synonym Full Names:Rho GTPase activating protein 15
NCBI Official Symbol:ARHGAP15  
NCBI Official Synonym Symbols:BM046  
NCBI Protein Information:rho GTPase-activating protein 15; rho-type GTPase-activating protein 15
UniProt Protein Name:Rho GTPase-activating protein 15
UniProt Synonym Protein Names:ArhGAP15; Rho-type GTPase-activating protein 15
Protein Family:Rho GTPase-activating protein
UniProt Gene Name:ARHGAP15  
UniProt Entry Name:RHG15_HUMAN
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ARHGAP15 Antibody (PACO07819)
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