UniProt Protein Function: | ARHGAP15: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 2q22.2-q22.3Cellular Component: membrane; cytosolBiological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction |
UniProt Protein Details: | |
NCBI Summary: | RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q53QZ3 |
NCBI GenInfo Identifier: | 28274758 |
NCBI Gene ID: | 55843 |
NCBI Accession: | AAO34684.1 |
UniProt Secondary Accession: | Q53QZ3,Q53R36, Q53RD7, Q53RT6, Q53SX9, Q584N9, Q6PJE6 Q86WP1, Q8IXX1, Q9NRL8 |
UniProt Related Accession: | Q53QZ3 |
Molecular Weight: | |
NCBI Full Name: | ARHGAP15 |
NCBI Synonym Full Names: | Rho GTPase activating protein 15 |
NCBI Official Symbol: | ARHGAP15Â Â |
NCBI Official Synonym Symbols: | BM046Â Â |
NCBI Protein Information: | rho GTPase-activating protein 15; rho-type GTPase-activating protein 15 |
UniProt Protein Name: | Rho GTPase-activating protein 15 |
UniProt Synonym Protein Names: | ArhGAP15; Rho-type GTPase-activating protein 15 |
Protein Family: | Rho GTPase-activating protein |
UniProt Gene Name: | ARHGAP15Â Â |
UniProt Entry Name: | RHG15_HUMAN |