The ARHGAP12 Polyclonal Antibody (PACO05758) is a valuable tool for researchers studying ARHGAP12, a protein involved in cell signaling and cytoskeleton organization. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the ARHGAP12 protein, allowing for precise detection and analysis in various cell types.ARHGAP12 is a Rho GTPase-activating protein that regulates the activity of Rho GTPases, key players in processes like cell migration, adhesion, and proliferation. Dysregulation of ARHGAP12 has been implicated in diseases like cancer, cardiovascular disorders, and neurological conditions.
Therefore, studying the function and expression of ARHGAP12 is crucial for understanding its role in disease pathogenesis and identifying potential therapeutic targets.With its ability to target ARHGAP12 and facilitate accurate analysis, the PACO05758 antibody is an essential asset for researchers investigating the molecular mechanisms involving ARHGAP12 and its potential implications in various diseases. Its reliability and specificity make it an ideal choice for studies in cell biology, cancer research, and other fields where ARHGAP12 is a focus of interest.
Antibody Name:
ARHGAP12 Antibody (PACO05758)
Antibody SKU:
PACO05758
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human ARHGAP12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ARHGAP12; Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12
UniProt Protein Function:
Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.Sequence similarities: Contains 1 PH domain.Contains 1 Rho-GAP domain.Contains 1 SH3 domain.Contains 2 WW domains.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
