The ARHGAP11B Polyclonal Antibody (CAB16587) is a valuable tool for researchers studying ARHGAP11B, a gene known for its involvement in brain development and evolution. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ARHGAP11B protein, researchers can accurately detect and analyze its expression in various tissue types.ARHGAP11B, a human-specific gene derived from a retrotransposition event, has been implicated in the development of the neocortex, the part of the brain responsible for higher cognitive functions.
Its unique evolutionary history and potential role in neurodevelopment make it an exciting target for further research in neuroscience and evolutionary biology. Understanding the function of ARHGAP11B may provide insights into the mechanisms underlying human brain evolution and development, as well as potential implications for neurological disorders.
Product Name:
ARHGAP11B Rabbit Polyclonal Antibody
SKU:
CAB16587
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 218-267 of human ARHGAP11B (NP_001034930.1).
Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix.
Purification Method:
Affinity purification
Gene ID:
89839
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARHGAP11B Rabbit pAb (CAB16587) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 2s.
