The ARG2 Polyclonal Antibody (CAB6355) is a valuable tool for research involving ARG2, a key enzyme involved in the regulation of arginine metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blot and immunohistochemistry.ARG2, also known as Arginase-2, plays a crucial role in the urea cycle by catalyzing the hydrolysis of arginine to ornithine and urea. Dysregulation of ARG2 expression has been implicated in various diseases, including cancer, cardiovascular disorders, and metabolic syndromes.
Understanding the function and regulation of ARG2 is essential for therapeutic targeting and drug development in these disease contexts.The ARG2 Polyclonal Antibody enables accurate detection and analysis of ARG2 protein expression in different cell types and tissues, making it an invaluable tool for studies in biochemistry, metabolism, and disease pathogenesis. Researchers can use this antibody to gain insights into the role of ARG2 in various biological processes and diseases, ultimately leading to new strategies for diagnosis and treatment.
Product Name:
Arginase 2 (ARG2) Rabbit Polyclonal Antibody
SKU:
CAB6355
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-354 of human Arginase 2 (ARG2) (NP_001163.1).
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.
Purification Method:
Affinity purification
Gene ID:
384
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Arginase 2 (ARG2) antibody (CAB6355) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
