The ARFGAP1 Polyclonal Antibody (PACO04717) is a valuable tool for researchers studying ARFGAP1, a protein involved in regulating membrane traffic and vesicle formation in cells. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ARFGAP1 protein, this antibody allows for the detection and analysis of ARFGAP1 in a variety of cell types, making it suitable for investigations in cell biology, molecular biology, and drug discovery.
ARFGAP1, also known as ADP-ribosylation factor GTPase-activating protein 1, plays a crucial role in maintaining proper cellular function by controlling the trafficking of vesicles within the cell. Dysregulation of ARFGAP1 has been linked to various diseases, including cancer and neurodegenerative disorders. By studying the function and regulation of ARFGAP1, researchers can gain insight into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.
