The ARF6 Polyclonal Antibody (CAB0988) is an essential tool for researchers studying ARF6, a small GTPase protein involved in regulating membrane trafficking and cytoskeletal reorganization. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in various research applications such as Western blotting.ARF6 is known for its role in regulating endocytic recycling and actin cytoskeleton dynamics, making it a key player in cell migration, invasion, and vesicular trafficking. Dysregulation of ARF6 has been implicated in cancer progression, making it a potential target for therapeutic interventions.
By using the ARF6 Polyclonal Antibody, researchers can effectively detect and analyze ARF6 protein expression in different cell types, advancing our understanding of its functions in health and disease.This antibody is a valuable tool for studies in cell biology, cancer research, and membrane trafficking, providing insights into the complex mechanisms governed by ARF6. Its use can lead to discoveries that may pave the way for developing novel treatments targeting ARF6-related pathways in various pathological conditions.
Product Name:
ARF6 Rabbit Polyclonal Antibody
SKU:
CAB0988
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human ARF6 (NP_001654.1).
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
Purification Method:
Affinity purification
Gene ID:
382
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ARF6 antibody (CAB0988) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
