The ARF4 Polyclonal Antibody (CAB7644) is a specialized tool for researchers studying ARF4, a protein involved in intracellular trafficking and signaling pathways. This antibody, produced in rabbits, is highly specific for detecting ARF4 in human samples and has been validated for use in Western blot applications. By specifically binding to ARF4, researchers can accurately measure and analyze the expression of this protein in various cell types.ARF4 is a key player in regulating vesicular transport and membrane traffic within cells, making it crucial for processes such as protein sorting, endocytosis, and organelle maintenance.
Dysregulation of ARF4 has been linked to diseases including cancer, neurodegenerative disorders, and metabolic conditions. By understanding the role of ARF4, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially develop targeted therapies.In summary, the ARF4 Polyclonal Antibody (CAB7644) is a valuable tool for researchers investigating the functions and implications of ARF4 in cellular processes and disease pathology. Its high specificity and sensitivity make it an ideal choice for studies in cell biology, biochemistry, and drug development.
Product Name:
ARF4 Rabbit Polyclonal Antibody
SKU:
CAB7644
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ARF4 (NP_001651.1).
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
378
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARF4 Rabbit pAb (CAB7644) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
