The ARC Antibody (PACO23635) is a polyclonal antibody designed for research involving the ARC protein, a key regulator of synaptic plasticity and memory formation in the brain. This antibody, produced in rabbits, is highly specific and reactive towards human samples, making it a reliable tool for studying the function and expression of ARC in various cellular and tissue samples.ARC, also known as Activity-Regulated Cytoskeleton-associated protein, is essential for the molecular mechanisms underlying the formation and maintenance of neuronal connections, which are crucial for learning and memory processes. Dysregulation of ARC expression has been linked to various neurological disorders such as Alzheimer's disease, autism, and schizophrenia, highlighting the importance of studying this protein in both normal and pathological conditions.
With its high specificity and sensitivity, the ARC Antibody (PACO23635) is validated for use in Western blot applications, allowing researchers to detect and analyze ARC protein levels in different cell types and tissues. By investigating the role of ARC in synaptic plasticity and memory formation, this antibody provides valuable insights into the molecular pathways involved in brain function and dysfunction, offering new avenues for therapeutic interventions in neurological disorders.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded human brain tissue using ARC antibody.
Western blot analysis of extracts from HeLa cells and A549 cells using ARC antibody. The lane on the left is treated with synthesized peptide.
Western blot analysis of extracts from HeLa cells, using ARC antibody.
Background:
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms:
Myp; NOL3; Nop30; Nucleolar protein 3; apoptosis repressor ARC
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
