The ARAP2 Polyclonal Antibody (CAB12254) is a valuable tool for researchers studying the ARAP2 protein, a crucial regulator of cell signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ARAP2 protein, this antibody enables researchers to detect and analyze ARAP2 levels in various cell types, facilitating studies in cell biology, signal transduction, and cancer research.ARAP2 is a multidomain protein that plays a key role in cellular processes such as cell migration, adhesion, and cytoskeletal organization. Its involvement in signaling pathways makes it a promising target for investigating diseases like cancer, cardiovascular disorders, and neurological conditions.
Understanding the function of ARAP2 is crucial for developing targeted therapies that can modulate cell signaling and potentially treat these diseases effectively.Overall, the ARAP2 Polyclonal Antibody (CAB12254) is an essential tool for researchers looking to delve deeper into the role of ARAP2 in cell signaling and disease mechanisms. Its high specificity and reliability make it a valuable asset in studies aiming to uncover the therapeutic potential of targeting ARAP2 in various pathological conditions.
Product Name:
ARAP2 Rabbit Polyclonal Antibody
SKU:
CAB12254
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1405-1704 of human ARAP2 (NP_056045.2).
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.
Purification Method:
Affinity purification
Gene ID:
116984
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARAP2 Rabbit pAb (CAB12254) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
