Aquaporin-4 Polyclonal Antibody (CAB2887) is a key tool for researchers studying aquaporin-4, a water channel protein primarily found in the central nervous system, specifically in the brain and spinal cord. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blotting applications. By binding to aquaporin-4, this antibody enables the detection and analysis of this important protein in various cell types, making it ideal for investigations in neuroscience and neurology research.
Aquaporin-4 plays a crucial role in regulating water transport in the central nervous system, contributing to processes such as brain water homeostasis and cerebrospinal fluid dynamics. Its involvement in various neurological conditions makes it a significant target for research in areas such as brain edema, multiple sclerosis, and neuromyelitis optica. Understanding the function and regulation of aquaporin-4 is essential for developing treatments that target these neurological disorders.
Product Name:
Aquaporin-4 (AQP4) Rabbit Polyclonal Antibody
SKU:
CAB2887
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 256-323 of human Aquaporin-4 (AQP4) (NP_001641.1).
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon.
Purification Method:
Affinity purification
Gene ID:
361
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SKOV3 cells, using Aquaporin-4 (AQP4) Rabbit pAb (CAB2887) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
