The AQP7 Polyclonal Antibody (PAC020987) is a valuable tool for researchers studying Aquaporin 7 (AQP7), a membrane protein involved in water and glycerol transport in various tissues, including adipose tissue and liver. This antibody is raised in rabbits and has high reactivity with human samples, making it a reliable choice for Western blot applications.Aquaporin 7 plays a crucial role in regulating water and glycerol balance within cells, making it essential for processes such as fat metabolism and energy homeostasis. Dysregulation of AQP7 has been associated with conditions like obesity, diabetes, and metabolic disorders.
By targeting AQP7 with this antibody, researchers can better understand its function in these contexts and potentially identify new therapeutic approaches for related diseases.Overall, the AQP7 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of Aquaporin 7 in various physiological and pathological processes, with the potential for advancing knowledge and treatment options in areas such as metabolism and obesity-related disorders.
Antibody Name:
AQP7 Antibody (PACO20987)
Antibody SKU:
PACO20987
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human AQP7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20987(AQP7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20987(AQP7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.
Synonyms:
aquaporin 7
UniProt Protein Function:
AQP7: Forms a channel for water and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, aquaporin familyChromosomal Location of Human Ortholog: 9p13Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; intercellular junctionMolecular Function: urea transmembrane transporter activity; water channel activity; glycerol channel activityBiological Process: glycerol transport; generation of precursor metabolites and energy; cellular water homeostasis; water transport; excretion; transmembrane transportDisease: Glycerol Quantitative Trait Locus
UniProt Protein Details:
NCBI Summary:
Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function. [provided by RefSeq, Jul 2008]
