The AQP4 Rabbit Monoclonal Antibody is a powerful tool for researchers studying aquaporin-4 (AQP4), a water channel protein found in the central nervous system and involved in the regulation of water transport. This highly specific antibody, produced in rabbits, is suitable for use in various applications such as immunohistochemistry and immunofluorescence.AQP4 plays a crucial role in maintaining water homeostasis in the brain and spinal cord, making it a key player in conditions like cerebral edema and multiple sclerosis.
By targeting AQP4, researchers can gain insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies.With its high reactivity towards human samples and excellent performance in various experimental settings, the AQP4 Rabbit Monoclonal Antibody is an essential tool for investigating the function and regulation of AQP4 in both normal and pathological conditions. Its versatility makes it a valuable asset for studies in neuroscience, neurology, and related fields.
Product Name:
Aquaporin-4 (AQP4) Rabbit Monoclonal Antibody
SKU:
CAB11210
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 256-323 of human Aquaporin-4 (AQP4) (NP_001641.1).
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon.
Purification Method:
Affinity purification
Gene ID:
361
Clone Number:
ARC54345
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Aquaporin-4 (AQP4) Rabbit mAb (CAB11210) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
