APP Rabbit Polyclonal Antibody (CAB11019)
- SKU:
- CAB11019
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | APP Rabbit Polyclonal Antibody |
SKU: | CAB11019 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human APP (NP_000475.1). |
Sequence: | MLPG LALL LLAA WTAR ALEV PTDG NAGL LAEP QIAM FCGR LNMH MNVQ NGKW DSDP SGTK TCID TKEG ILQY CQEV YPEL QITN VVEA NQPV TIQN WCKR |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; APP |
Positive Sample: | U-87MG |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein, clathrin-coated pit. |
Calculated MW: | 87kDa |
Observed MW: | 100-140kDa |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 351 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |