The APOL4 Polyclonal Antibody (PAC023795) is a valuable tool for researchers studying the APOL4 protein, a component of the apolipoprotein L gene family. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the APOL4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies focused on immunology and cancer research.
APOL4 is known to play a role in lipid metabolism and is associated with various diseases, including cancer and cardiovascular disorders. Research into the function and regulation of APOL4 is essential for identifying potential therapeutic targets and developing innovative treatment strategies for these conditions. By utilizing the APOL4 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and pave the way for novel therapeutic interventions.
Synthesized peptide derived from C-terminal of human APOL4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from LOVO cells and HT-29cells, using APOL4 antibody.
Immunofluorescence analysis of MCF-7 cells, using APOL4 antibody.
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using APOL4 antibody.
Background:
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver By similarity.
APOL4: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Belongs to the apolipoprotein L family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Lipid-binding; SecretedChromosomal Location of Human Ortholog: 22q11.2-q13.2Cellular Component: extracellular space; intracellular membrane-bound organelleDisease: Schizophrenia
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]
