The APOH Polyclonal Antibody (CAB1220) is a valuable tool for researchers studying the APOH protein, also known as Beta-2-glycoprotein 1. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. APOH is a key protein involved in blood clotting, lipid metabolism, and immune regulation. Dysregulation of APOH has been implicated in various diseases, including thrombosis, cardiovascular disease, and autoimmune disorders.
By using this antibody, researchers can detect and analyze the APOH protein in different cell types, providing insights into its function and potential roles in disease pathogenesis.With its ability to target APOH, the CAB1220 antibody is essential for studies in immunology, hemostasis, and cardiovascular research. Understanding the role of APOH in health and disease could lead to the development of novel therapies for a range of conditions, making this antibody a valuable asset in the lab.
Product Name:
APOH Rabbit Polyclonal Antibody
SKU:
CAB1220
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-345 of human APOH (NP_000033.2).
Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.
Purification Method:
Affinity purification
Gene ID:
350
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 22Rv1 cells, using APOH Rabbit pAb (CAB1220) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
