APOH Rabbit Polyclonal Antibody (CAB1220)
- SKU:
- CAB1220
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | APOH Rabbit Polyclonal Antibody |
SKU: | CAB1220 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-345 of human APOH (NP_000033.2). |
Sequence: | RTCP KPDD LPFS TVVP LKTF YEPG EEIT YSCK PGYV SRGG MRKF ICPL TGLW PINT LKCT PRVC PFAG ILEN GAVR YTTF EYPN TISF SCNT GFYL NGAD SAKC TEEG KWSP ELPV CAPI ICPP PSIP TFAT LRVY KPSA GNNS LYRD TAVF ECLP QHAM FGND TITC TTHG NWTK LPEC REVK CPFP SRPD NGFV NYPA KPTL YYKD KATF GCHD GYSL DGPE EIEC TKLG NWSA MPSC KASC KVPV KKAT VVYQ GERV KIQE KFKN GMLH GDKV SFFC KNKE KKCS YTED AQCI DGTI EVPK CFKE HSSL AFWK TDAS DVKP C |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | BG; B2G1; B2GP1; APOH |
Positive Sample: | 22Rv1 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 38kDa |
Observed MW: | 45kDa |
Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.
Purification Method: | Affinity purification |
Gene ID: | 350 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |