Based on the information in the provided URL (https://www.assaygenie.com/apobec4-antibody-paco15480/), the APOBEC4 Polyclonal Antibody (PAC015480) is a high-quality research tool designed for the study of APOBEC4, a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of proteins. This antibody is raised in rabbits and has been validated for use in various experimental applications, including Western blotting.APOBEC4 is known to be involved in RNA editing and other nucleic acid modification processes, making it a key player in the regulation of gene expression and cellular functions. Research on APOBEC4 is important for understanding its role in biological processes such as RNA editing, DNA repair, and oxidative stress response.
Additionally, dysregulation of APOBEC4 has been linked to various diseases, including cancer and autoimmune disorders.By using the APOBEC4 Polyclonal Antibody (PAC015480), researchers can accurately detect and analyze APOBEC4 protein expression in different cell types and experimental conditions. This antibody is a valuable tool for studies in molecular biology, cancer research, and immunology, providing insight into the functions and mechanisms of APOBEC4 in normal and disease states.
Antibody Name:
APOBEC4 Antibody (PACO15480)
Antibody SKU:
PACO15480
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human APOBEC4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15480(APOBEC4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.
Synonyms:
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
UniProt Protein Function:
APOBEC4: Putative C to U editing enzyme whose physiological substrate is not yet known. Belongs to the cytidine and deoxycytidylate deaminase family.Protein type: Hydrolase; EC 3.5.4.-Chromosomal Location of Human Ortholog: 1q25.3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]
