APOBEC3D/APOBEC3F Antibody (PACO23463)
- SKU:
- PACO23463
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
APOBEC3D/APOBEC3F Antibody (PACO23463)
The APOBEC3D/APOBEC3F Antibody (PAC023463) is a valuable tool for research involving APOBEC3D and APOBEC3F, key members of the APOBEC family of cytidine deaminases with roles in innate immunity and anti-viral defense mechanisms. This antibody, produced in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications. By binding to the APOBEC3D and APOBEC3F proteins, researchers can detect and analyze these important molecules in a variety of cell types, making it ideal for investigations in virology, immunology, and cancer research.The APOBEC3 family of proteins are known for their ability to mutate viral genomes, thereby providing a crucial defense mechanism against viral infections.
APOBEC3D and APOBEC3F in particular have been linked to restricting the replication of various viruses, including HIV-1 and HBV. Understanding the function and regulation of these proteins is instrumental in uncovering potential targets for antiviral therapies and enhancing our knowledge of host-virus interactions. By utilizing the APOBEC3D/APOBEC3F Antibody in research studies, scientists can gain valuable insights into the mechanisms underlying viral restriction and immune responses, ultimately paving the way for innovative approaches to combat viral infections and develop novel treatments for viral-related diseases.
| Antibody Name: | APOBEC3D/APOBEC3F Antibody (PACO23463) |
| Antibody SKU: | PACO23463 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human APOBEC3D/F. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from MCF-7 cells and COS-7cells, using APOBEC3D/F antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human placenta tissue using APOBEC3D/F antibody. |
| Background: | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. |
| Synonyms: | Probable DNA dC->dU-editing enzyme APOBEC-3D; EC 3.5.4.-; APOBEC3D; |
| UniProt Protein Function: | APOBEC3D: Probable DNA cytidine deaminase involved in foreign DNA clearance. May provide cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses. Belongs to the cytidine and deoxycytidylate deaminase family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.5.4.- Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytoplasm Molecular Function:zinc ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Biological Process: negative regulation of retroviral genome replication; innate immune response; defense response to virus |
| UniProt Code: | Q96AK3 |
| NCBI GenInfo Identifier: | 48474596 |
| NCBI Gene ID: | |
| NCBI Accession: | Q96AK3.1 |
| UniProt Secondary Accession: | Q96AK3,Q5JZ91, Q7Z2N2, Q7Z2N5, Q7Z2N6, |
| Molecular Weight: | 46598 |
| NCBI Full Name: | DNA dC-> |
| UniProt Protein Name: | DNA dC->dU-editing enzyme APOBEC-3D |
| Protein Family: | DNA dC->dU-editing enzyme |
| UniProt Gene Name: | APOBEC3DÂ Â |
| UniProt Entry Name: | ABC3D_HUMAN |
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