The APOBEC3B Polyclonal Antibody (CAB9010) is a valuable tool for researchers studying APOBEC3B, a member of the APOBEC family of cytidine deaminases known for their roles in DNA editing and antiviral defense mechanisms. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for use in various research applications such as Western blotting.APOBEC3B is particularly interesting due to its implications in cancer development and progression. Research suggests that APOBEC3B may contribute to the mutational landscape of various cancers, making it a potential therapeutic target in oncology research. By detecting and studying APOBEC3B using this antibody, researchers can gain insights into its functions and potential roles in disease pathways.
Furthermore, APOBEC3B has been linked to viral restriction and immunity, highlighting its importance in antiviral defense mechanisms. By utilizing this antibody, researchers can explore the interactions between APOBEC3B and viral pathogens, shedding light on the molecular mechanisms underlying viral infections and host immune responses.Overall, the APOBEC3B Polyclonal Antibody (CAB9010) is a valuable tool for researchers interested in studying the functions and implications of APOBEC3B in cancer research, virology, and beyond. Its high specificity and reactivity make it a reliable choice for detecting and analyzing APO
Product Name:
APOBEC3B Rabbit Polyclonal Antibody
SKU:
CAB9010
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 151-250 of human APOBEC3B (NP_004891.5).
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9582
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using APOBEC3B Rabbit pAb (CAB9010) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
