APOBEC3A Rabbit Polyclonal Antibody (CAB12399)
- SKU:
- CAB12399
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | APOBEC3A Rabbit Polyclonal Antibody |
SKU: | CAB12399 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human APOBEC3A (NP_663745.1). |
Sequence: | MEAS PASG PRHL MDPH IFTS NFNN GIGR HKTY LCYE VERL DNGT SVKM DQHR GFLH NQAK NLLC GFYG RHAE LRFL DLVP SLQL DPAQ IYRV TWFI SWSP CFSW GCAG EVRA FLQE NTHV RLRI FAAR IYDY DPLY KEAL QMLR DAGA QVSI MTYD EFKH CWDT FVDH QGCP FQPW DGLD EHSQ ALSG RLRA ILQN QGN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | A3A; ARP3; PHRBN; bK150C2.1; APOBEC3A |
Positive Sample: | 293T transfected with APOBEC3A |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 23kDa |
Observed MW: | 26kDa |
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 200315 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |