Apoa1 Antibody (PACO64139)
- SKU:
- PACO64139
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Apoa1 Antibody (PACO64139)
The APOA1 Polyclonal Antibody (PAC064139) is a valuable tool for researchers studying apolipoprotein A1 (APOA1), a protein involved in lipid metabolism and cardiovascular health. Raised in rabbits, this antibody is highly specific and reacts strongly with human samples, making it ideal for use in Western blot applications. APOA1 is a major component of high-density lipoprotein (HDL), playing a key role in the transport of cholesterol from tissues to the liver for excretion. Research has shown that APOA1 levels are inversely correlated with the risk of cardiovascular disease, making it a promising target for therapeutic interventions.
By using the APOA1 Polyclonal Antibody, researchers can accurately detect and quantify APOA1 protein levels in various cell types and tissues, allowing for detailed analysis of its role in lipid metabolism and cardiovascular function. This antibody is a valuable tool for investigations into the molecular mechanisms underlying cardiovascular diseases and the development of novel therapies targeting APOA1.
| Antibody Name: | Apoa1 Antibody (PACO64139) |
| Antibody SKU: | PACO64139 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:1000-1:5000 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Apoa1 protein (19-259AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat Heart tissue, Rat Liver tissue, Rat Spleen tissue, Rat Lung tissue, Rat Kidney tissue, Rat Brain tissue, Rat Stomach tissue. All lanes: Apoa1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 31 kDa. Observed band size: 31 kDa. |
| Background: | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
| Synonyms: | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I)], Apoa1 |
| UniProt Protein Function: | Function: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
| UniProt Protein Details: | Subunit structure: Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin Subcellular location: Secreted. Tissue specificity: Major protein of plasma HDL, also found in chylomicrons. Post-translational modification: Phosphorylation sites are present in the extracelllular medium Sequence similarities: Belongs to the apolipoprotein A1/A4/E family. |
| NCBI Summary: | major component of high density lipoprotein (HDL) that is involved in intercellular cholesterol transport in astrocytes; cofactor for lecithin cholesterolacyltransferase (LCAT) [RGD] |
| UniProt Code: | P04639 |
| NCBI GenInfo Identifier: | 6978515 |
| NCBI Gene ID: | 25081 |
| NCBI Accession: | NP_036870.1 |
| UniProt Secondary Accession: | P04639,O08877, O09054, Q5EBB2, |
| UniProt Related Accession: | P04639 |
| Molecular Weight: | |
| NCBI Full Name: | apolipoprotein A-I preproprotein |
| NCBI Synonym Full Names: | apolipoprotein A-I |
| NCBI Official Symbol: | Apoa1Â Â |
| NCBI Official Synonym Symbols: | apoA-IÂ Â |
| NCBI Protein Information: | apolipoprotein A-I; apo-AI; apolipoprotein A1; apolipoprotein A-1; preproapolipoprotein A-I |
| UniProt Protein Name: | Apolipoprotein A-I |
| UniProt Synonym Protein Names: | Apolipoprotein A1 |
| Protein Family: | Apolipoprotein |
| UniProt Gene Name: | Apoa1Â Â |
| UniProt Entry Name: | APOA1_RAT |
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