APLP2 Rabbit Polyclonal Antibody (CAB5455)
- SKU:
- CAB5455
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | APLP2 Rabbit Polyclonal Antibody |
SKU: | CAB5455 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 370-580 of human APLP2 (NP_001633.1). |
Sequence: | PTND VDVY FETS ADDN EHAR FQKA KEQL EIRH RNRM DRVK KEWE EAEL QAKN LPKA ERQT LIQH FQAM VKAL EKEA ASEK QQLV ETHL ARVE AMLN DRRR MALE NYLA ALQS DPPR PHRI LQAL RRYV RAEN KDRL HTIR HYQH VLAV DPEK AAQM KSQV MTHL HVIE ERRN QSLS LLYK VPYV AQEI QEEI DELL QEQR ADMD QFTA SIS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | APPH; APPL2; CDEBP; APLP-2; APLP2 |
Positive Sample: | Mouse brain,Mouse heart,Mouse testis,Rat brain,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 87kDa |
Observed MW: | 87kDa |
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 334 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |