The APLP2 Polyclonal Antibody (CAB5455) is a vital tool for researchers studying the Amyloid beta (A4) precursor-like protein 2 (APLP2) in various biological processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been specifically validated for use in Western blotting applications. By targeting the APLP2 protein, researchers can effectively detect and analyze its expression in different cell types, making it an essential reagent for studies in neuroscience, Alzheimer's disease, and cellular signaling pathways.APLP2 is a member of the amyloid precursor protein (APP) family and plays a critical role in synaptic plasticity, neuronal development, and the formation of amyloid plaques in Alzheimer's disease.
Its involvement in these processes makes it a promising target for investigating neurodegenerative disorders and developing potential therapeutic interventions. Understanding the functions and mechanisms of APLP2 can provide valuable insights into the pathophysiology of Alzheimer's disease and other neurodegenerative conditions, paving the way for novel treatment strategies.
Product Name:
APLP2 Rabbit Polyclonal Antibody
SKU:
CAB5455
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 370-580 of human APLP2 (NP_001633.1).
Cell membrane, Nucleus, Single-pass type I membrane protein.
Calculated MW:
87kDa
Observed MW:
87kDa
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
334
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using APLP2 Polyclonal Antibody (CAB5455) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
