The APLP1 Polyclonal Antibody (CAB6870) is a valuable tool for researchers studying amyloid precursor-like protein 1 (APLP1), a transmembrane protein with potential roles in neuronal development and synaptic function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.APLP1 is a member of the amyloid precursor protein (APP) family and is known to interact with proteins involved in Alzheimer's disease pathology. Research suggests that APLP1 may play a role in synaptic plasticity and neuronal survival, making it a promising target for investigations into neurodegenerative disorders.
By specifically binding to APLP1, this antibody enables researchers to detect and analyze the protein in various cell types, providing valuable insights into its functions and potential implications in disease mechanisms. Its application in neuroscience research makes it a valuable tool for studies aiming to unravel the complexities of neurological disorders and identify novel therapeutic targets.
Product Name:
APLP1 Rabbit Polyclonal Antibody
SKU:
CAB6870
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 285-490 of human APLP1 (NP_005157.1).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
72kDa
Observed MW:
72kDa
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
333
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using APLP1 Rabbit pAb (CAB6870) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
