The APLP1 Polyclonal Antibody (CAB2634) is a valuable tool for researchers studying Amyloid beta precursor-like protein 1 (APLP1), a key protein involved in Alzheimer's disease and other neurological disorders. This antibody, generated in rabbits, is highly specific to human APLP1 and has been validated for use in applications such as Western blot and immunohistochemistry.APLP1 is a transmembrane protein that plays a crucial role in neuronal development, synaptic function, and maintenance of neuronal integrity. Dysregulation of APLP1 has been linked to the pathogenesis of Alzheimer's disease, making it an important target for therapeutic interventions.
The APLP1 Polyclonal Antibody enables precise detection and localization of APLP1 in various cell types and tissues, providing valuable insights into its function and regulation.With its high specificity and sensitivity, the APLP1 Polyclonal Antibody is an essential tool for researchers seeking to understand the role of APLP1 in neurological disorders and develop potential treatments targeting this protein. Its reliable performance and versatility make it a valuable asset for studies in neuroscience, neurodegenerative diseases, and drug discovery efforts aimed at combating Alzheimer's disease and related conditions.
Product Name:
APLP1 Rabbit Polyclonal Antibody
SKU:
CAB2634
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 470-580 of human APLP1 (NP_005157.1).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
72kDa
Observed MW:
100kDa
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
333
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using APLP1 antibody (CAB2634) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
