The APLP1 Monoclonal Antibody is a valuable tool for researchers studying the amyloid precursor-like protein 1 (APLP1), a protein involved in Alzheimer's disease and neurological development. This antibody, generated in mice, is highly specific to APLP1 in human samples and is validated for use in various applications such as immunohistochemistry and immunofluorescence.APLP1 is known to play a role in neuronal development and synaptic plasticity, making it a key player in brain function and dysfunction. Research into APLP1 has the potential to uncover new insights into neurodegenerative diseases, cognitive function, and neurological disorders.
The APLP1 Monoclonal Antibody enables researchers to detect and analyze APLP1 expression in different tissues and cell types, making it an essential tool for studies in neuroscience and neurobiology.By understanding the function and regulation of APLP1, researchers may uncover new therapeutic targets and strategies for treating Alzheimer's disease and other neurological conditions. The APLP1 Monoclonal Antibody is a valuable asset for those investigating the role of APLP1 in health and disease, with the potential to advance our understanding of the molecular mechanisms underlying neurodegeneration.
Product Name:
APLP1 Monoclonal Antibody
SKU:
CAB23426
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant protein of human APLP1.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
APLP; APLP1
Positive Sample:
A-549
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
72kDa
Observed MW:
100kDa
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
333
Clone Number:
ARC60846
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of A-549, using APLP1 Rabbit mAb (CAB23426) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
