APITD1 Rabbit Polyclonal Antibody (CAB8293)
- SKU:
- CAB8293
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | APITD1 Rabbit Polyclonal Antibody |
SKU: | CAB8293 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human APITD1 (NP_954988.1). |
Sequence: | MEEE AETE EQQR FSYQ QRLK AAVH YTVG CLCE EVAL DKEM QFSK QTIA AISE LTFR QCEN FAKD LEMF ARHA KRTT INTE DVKL LARR SNSL LKYI TDKS EEIA QINL ERKA QKKK KSED GSKN SRQP AEAG VVES EN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MHF1; APITD1; CENP-S; FAAP16 |
Positive Sample: | U-251MG,SW620,NCI-H460,MCF7,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, centromere, kinetochore. |
Calculated MW: | 16kDa |
Observed MW: | 16kDa |
This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.
Purification Method: | Affinity purification |
Gene ID: | 378708 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |