APEX1/APE1 Rabbit Monoclonal Antibody (CAB11238)
- SKU:
- CAB11238
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | APEX1/APE1 Rabbit Monoclonal Antibody |
SKU: | CAB11238 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human APEX1/APE1 (P27695). |
Sequence: | MPKR GKKG AVAE DGDE LRTE PEAK KSKT AAKK NDKE AAGE GPAL YEDP PDQK TSPS GKPA TLKI CSWN VDGL RAWI KKKG LDWV KEEA PDIL CLQE TKCS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | APE; APX; APE1; APEN; APEX; HAP1; REF1; APEX1/APE1 |
Positive Sample: | HeLa,A-431,NIH/3T3,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus, Nucleus speckle, nucleolus. |
Calculated MW: | 36kDa |
Observed MW: | 36kDa |
The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.
Purification Method: | Affinity purification |
Gene ID: | 328 |
Clone Number: | ARC0556 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |