The APC Rabbit Monoclonal Antibody (CAB17912) is a powerful tool for researchers studying APC, a key protein involved in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in human samples, making it ideal for various experimental applications such as immunofluorescence and flow cytometry.APC, also known as adenomatous polyposis coli, is a tumor suppressor protein that plays a crucial role in maintaining genomic stability and controlling cell proliferation. Dysregulation of APC function has been linked to various types of cancers, making it a promising target for cancer research and drug development.
By utilizing the APC Rabbit Monoclonal Antibody (CAB17912), researchers can accurately detect and measure APC expression levels in different cell types and tissues, providing valuable insights into its biological functions and potential therapeutic implications. This antibody is a valuable resource for studies in oncology, cell biology, and molecular medicine, paving the way for new advancements in cancer treatment and personalized medicine.
Product Name:
APC Rabbit Monoclonal Antibody
SKU:
CAB17912
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human APC (NP_000029.2).
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Purification Method:
Affinity purification
Gene ID:
324
Clone Number:
ARC0346
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using APC Rabbit mAb (CAB17912) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
