APC Rabbit Monoclonal Antibody (CAB17912)
- SKU:
- CAB17912
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | APC Rabbit Monoclonal Antibody |
SKU: | CAB17912 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human APC (NP_000029.2). |
Sequence: | MAAA SYDQ LLKQ VEAL KMEN SNLR QELE DNSN HLTK LETE ASNM KEVL KQLQ GSIE DEAM ASSG QIDL LERL KELN LDSS NFPG VKLR SKMS LRSY GSRE |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46; APC |
Positive Sample: | SW480,Mouse brain,Mouse lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane. |
Calculated MW: | 312kDa |
Observed MW: | 160kDa |
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Purification Method: | Affinity purification |
Gene ID: | 324 |
Clone Number: | ARC0346 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |