The APC Polyclonal Antibody (CAB2818) is a valuable tool for researchers studying APC, a key protein involved in antigen presentation and immune response. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the APC protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology, infectious diseases, and cancer research.APC, or antigen presenting cell, plays a crucial role in the activation of T-cells and the initiation of immune responses.
Understanding the function and expression of APC is fundamental for unraveling the complexities of the immune system and developing targeted therapies for conditions such as infectious diseases, autoimmune disorders, and cancer. The APC Polyclonal Antibody (CAB2818) provides a reliable tool for researchers to explore the role of APC in health and disease, ultimately advancing our understanding of immune regulation and therapeutic interventions.
Product Name:
APC Rabbit Polyclonal Antibody
SKU:
CAB2818
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_000029.2).
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Purification Method:
Affinity purification
Gene ID:
324
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using APC Rabbit pAb (CAB2818) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
