APC Rabbit Polyclonal Antibody (CAB2818)
- SKU:
- CAB2818
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | APC Rabbit Polyclonal Antibody |
SKU: | CAB2818 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_000029.2). |
Sequence: | QSKE NQVS AKGT WRKI KENE FSPT NSTS QTVS SGAT NGAE SKTL IYQM APAV SKTE DVWV RIED CPIN NPRS GRSP TGNT PPVI DSVS EKAN PNIK DSKD NQAK QNVG NGSV PMRT VGLE NRLN SFIQ VDAP DQKG TEIK PGQN NPVP VSET NESS IVER T |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46; APC |
Positive Sample: | SW480,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane. |
Calculated MW: | 312kDa |
Observed MW: | 150kDa |
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Purification Method: | Affinity purification |
Gene ID: | 324 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |