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APC Anti-Rat CD44H Antibody [OX-49] (AGEL2428)

SKU:
AGEL2428
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Rat
Host Species:
Mouse
Isotype:
Mouse IgG2a, κ
Clone:
OX-49
Conjugation:
APC
$167 - $347
Frequently bought together:

Description

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APC Anti-Rat CD44H Antibody [OX-49]

The Rat CD44H Monoclonal Antibody (OX-49, AGEL2428) is a specialized tool for researchers delving into the realm of cellular adhesion and migration. This antibody, generated against CD44H in rats, exhibits exceptional specificity and sensitivity towards rat samples, particularly in flow cytometry and immunohistochemistry applications. By specifically recognizing and binding to the CD44H protein, this antibody enables precise detection and analysis in diverse experimental systems, offering a valuable asset for investigations in fields such as cell biology and immunology.CD44H, a variant of the CD44 cell surface glycoprotein, plays a key role in cell-cell interactions and cell signaling processes, particularly in relation to cell adhesion and migration.

Its involvement in these fundamental cellular activities makes it a crucial target for research aimed at understanding mechanisms underlying development, tissue regeneration, and disease progression. By elucidating the functions of CD44H, researchers can gain insights into various physiological and pathological processes, paving the way for innovative therapeutic approaches targeting conditions related to cellular adhesion dysregulation.

Product Title:APC Anti-Rat CD44H Antibody [OX-49]
SKU:AGEL2428
Size:50 Tests, 100 Tests, 200 Tests
Clone No:OX-49
Synonyms:Pgp-1; H-CAM; CD44s;CD44H;
Host Species:Mouse
Reactivity:Rat
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P26051
Gene ID:12505
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.

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